abstract：:A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated prote...

journal_title：Trends in cell biology

authors： Tsegaye MA,Schafer ZT

更新日期：2017-11-01 00:00:00

abstract：:Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the cross...

journal_title：Trends in cell biology

authors： Thelen AM,Zoncu R

更新日期：2017-11-01 00:00:00

abstract：:Somatic stem cells maintain tissue homeostasis by organizing themselves in such a way that they can maintain proliferative output while simultaneously protecting themselves from DNA damage that may lead to oncogenic transformation. There is considerable debate about how such stem cell compartments are organized. Burge...

journal_title：Trends in cell biology

authors： Yousefi M,Li L,Lengner CJ

更新日期：2017-10-01 00:00:00

abstract：:Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Sma...

journal_title：Trends in cell biology

authors： Budi EH,Duan D,Derynck R

更新日期：2017-09-01 00:00:00

abstract：:Whereas physics seeks for universal laws underlying natural phenomena, biology accounts for complexity and specificity of molecular details. Contemporary biological physics requires people capable of working at this interface. New programs prepare scientists who transform respective disciplinary views into innovative ...

journal_title：Trends in cell biology

authors： Riveline D,Kruse K

更新日期：2017-08-01 00:00:00

abstract：:Asymmetric cell division (ACD) gives rise to two daughter cells with distinct fates. ACD is widely used during development and by many types of adult stem cells during tissue homeostasis and regeneration. ACD can be regulated by extrinsic cues, such as signaling molecules, as well as by intrinsic factors, such as orga...

journal_title：Trends in cell biology

authors： Xie J,Wooten M,Tran V,Chen X

更新日期：2017-07-01 00:00:00

abstract：:Why some genes are more popular than others remains an open question, but one example of this phenomenon involves the genes controlling planar cell polarity (PCP), the polarization of cells within a plane of a tissue. Indeed, the so-called 'core' PCP genes such as dishevelled, frizzled, and prickle have been extensive...

journal_title：Trends in cell biology

authors： Adler PN,Wallingford JB

更新日期：2017-05-01 00:00:00

abstract：:The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regula...

journal_title：Trends in cell biology

authors： Kamenz J,Hauf S

更新日期：2017-01-01 00:00:00

abstract：:Recent advances in genome engineering are starting a revolution in biological research and translational applications. The clustered regularly interspaced short palindromic repeats (CRISPR)-associated RNA-guided endonuclease CRISPR associated protein 9 (Cas9) and its variants enable diverse manipulations of genome fun...

journal_title：Trends in cell biology

authors： Wang F,Qi LS

更新日期：2016-11-01 00:00:00

abstract：:Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...

journal_title：Trends in cell biology

authors： Goldstein B,King N

更新日期：2016-11-01 00:00:00

abstract：:The Hippo signaling network integrates diverse upstream signals to control cell fate decisions and regulate organ growth. Recent studies have provided new insights into the cellular organization of Hippo signaling, its relationship to cell-cell junctions, and how the cytoskeleton modulates Hippo signaling. Cell-cell j...

journal_title：Trends in cell biology

authors： Sun S,Irvine KD

更新日期：2016-09-01 00:00:00

abstract：:Microbiology and cell biology both involve the study of cells, albeit at different levels of complexity and scale. Interactions between both fields during the past 25 years have led to major conceptual and technological advances that have reshaped the whole biology landscape and its biomedical applications. ...

journal_title：Trends in cell biology

authors： Pizarro-Cerdá J,Cossart P

更新日期：2016-07-01 00:00:00

abstract：:The architecture of the interphase nucleus remains a treasure trove for explorers of the 3D folding of macromolecules, like DNA, and of their related functions. Only recently has there been insight into how transient interactions of the genome and its associated proteins, in space and time, facilitate transcription, r...

journal_title：Trends in cell biology

authors： Gasser SM

更新日期：2016-07-01 00:00:00

abstract：:If eukaryotes arose through a merger between archaea and bacteria, what did the first true eukaryotic cell look like? A major step toward an answer came with the discovery of Lokiarchaeum, an archaeon whose genome encodes small GTPases related to those used by eukaryotes to regulate membrane traffic. Although 'Loki' c...

journal_title：Trends in cell biology

authors： Dey G,Thattai M,Baum B

更新日期：2016-07-01 00:00:00

abstract：:The glycoproteome, the ensemble of glycans and their carrier proteins, plays major roles in multicellular life by regulating cell interactions with their environment. How information is encoded into the glycome, in other words how glycosylation is modulated in response to signals, remains largely unclear. Glycosylatio...

journal_title：Trends in cell biology

authors： Bard F,Chia J

更新日期：2016-05-01 00:00:00

abstract：:Ubiquinone (UQ; also known as coenzyme Q; CoQ) is a mobile component of the mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone state. Despite this, UQ is also believed to be a membrane antioxidant. These properties place UQ at the center of hotly debated questions about how mi...

journal_title：Trends in cell biology

authors： Wang Y,Hekimi S

更新日期：2016-05-01 00:00:00

abstract：:'Secrete-and-sense cells' can communicate by secreting a signaling molecule while also producing a receptor that detects the molecule. The cell can potentially 'talk' to itself ('self-communication') or talk to neighboring cells with the same receptor ('neighbor communication'). The predominant forms of secrete-and-se...

journal_title：Trends in cell biology

authors： Doğaner BA,Yan LKQ,Youk H

更新日期：2016-04-01 00:00:00

abstract：:Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides. This form of iron-dependent cell death is genetically, biochemically, and morp...

journal_title：Trends in cell biology

authors： Yang WS,Stockwell BR

更新日期：2016-03-01 00:00:00

abstract：:Gene editing in zebrafish has begun to reveal discordance between mutant phenotypes and those associated with knockdown via morpholino oligonucleotides (MOs). These studies suggest that MOs should not be used as a standalone tool and underscore the need for guidelines that require defined mutants to assess gene functi...

journal_title：Trends in cell biology

authors： Lawson ND

更新日期：2016-02-01 00:00:00

abstract：:Chloroplasts depend on the nucleus for much of their proteome. Consequently, strong transcriptional coordination exists between the genomes, which is attuned to the developmental and physiological needs of the organelle. Recent studies highlight that the post-translational modifier ubiquitin adds another layer to plas...

journal_title：Trends in cell biology

authors： Hua Z,Vierstra RD

更新日期：2016-01-01 00:00:00

abstract：:The manner by which the organization and behaviors of cells arise from the activities of their constituent molecules remains poorly understood. Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes ...

journal_title：Trends in cell biology

authors： Needleman D

更新日期：2015-12-01 00:00:00

abstract：:Collective cell migration results from the establishment and maintenance of collective polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell migration depends on a reciprocal process between cell-intrinsic multicellular organization with leader-follower cell behavior and results in ...

journal_title：Trends in cell biology

authors： Haeger A,Wolf K,Zegers MM,Friedl P

更新日期：2015-09-01 00:00:00

abstract：:The number of invited women speakers at scientific meetings is much less than their proportion in a field. This means that women have fewer venues to present their research, less opportunity to increase their professional network, and smaller chances of promotion and financial support. The paucity of women speakers al...

journal_title：Trends in cell biology

authors： Masur SK

更新日期：2015-08-01 00:00:00

abstract：:Intracellular bacteria including major pathogens live in the cytoplasm or in cytoplasmic vacuoles within their host cell. However, some can invade more unusual intracellular niches such as the eukaryotic nucleus. Phylogenetically diverse intranuclear bacteria have been discovered in various protist, arthropod, marine ...

journal_title：Trends in cell biology

authors： Schulz F,Horn M

更新日期：2015-06-01 00:00:00

abstract：:Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunct...

journal_title：Trends in cell biology

authors： Slaats GG,Giles RH

更新日期：2015-06-01 00:00:00

abstract：:Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals...

journal_title：Trends in cell biology

authors： Driskell RR,Watt FM

更新日期：2015-02-01 00:00:00

abstract：:Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play important roles in diverse biological processes. As a class, lncRNAs are generally enriched in the nucleus and, specifically, within the chromatin-associated fraction. Consistent with their localization, many lncRNAs have been implicated in ...

journal_title：Trends in cell biology

authors： Quinodoz S,Guttman M

更新日期：2014-11-01 00:00:00

abstract：:Cells possess an extensive network of components to safeguard proteome integrity and maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines in performance, as may be the case during aging, newly synthesized proteins are no longer able to fold efficiently and metastable proteins lose ...

journal_title：Trends in cell biology

authors： Hipp MS,Park SH,Hartl FU

更新日期：2014-09-01 00:00:00

abstract：:Solid tumors typically develop hostile microenvironments characterized by irregular vascularization and poor oxygen (O2) and nutrient supply. Whereas normal cells modulate anabolic and catabolic pathways in response to changes in nutrient availability, cancer cells exhibit unregulated growth even under nutrient scarci...

journal_title：Trends in cell biology

authors： Ackerman D,Simon MC

更新日期：2014-08-01 00:00:00

abstract：:The organization of cells into interconnected structures such as animal tissues requires a sophisticated system directing receptors and adhesion proteins to the cell surface. The Rab11 small G proteins (Rab11a, b, and Rab25) of the Ras superfamily are master regulators of the surface expression of receptors and adhesi...

journal_title：Trends in cell biology

authors： Welz T,Wellbourne-Wood J,Kerkhoff E

更新日期：2014-07-01 00:00:00

abstract：:Long-distance cell-cell communication is essential for organ development and function. Whereas neurons communicate at long distances by transferring signals at sites of direct contact (i.e., at synapses), it has been presumed that the only way other cell types signal is by dispersing signals through extracellular flui...

journal_title：Trends in cell biology

authors： Kornberg TB,Roy S

更新日期：2014-06-01 00:00:00

abstract：:Eukaryotic cells contain numerous cytosolic and nuclear iron-sulfur (Fe/S) proteins that perform key functions in metabolic catalysis, iron regulation, protein translation, DNA synthesis, and DNA repair. Synthesis of Fe/S clusters and their insertion into apoproteins are essential for viability and are conserved in eu...

journal_title：Trends in cell biology

authors： Netz DJ,Mascarenhas J,Stehling O,Pierik AJ,Lill R

更新日期：2014-05-01 00:00:00

abstract：:Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate...

journal_title：Trends in cell biology

authors： Traylor-Knowles N,Palumbi SR

更新日期：2014-05-01 00:00:00

abstract：:During the past 15 years mass spectrometry (MS)-based analyses have become established as the method of choice for direct protein identification and measurement. Owing to the remarkable improvements in the sensitivity and resolution of MS instruments, this technology has revolutionised the opportunities available for ...

journal_title：Trends in cell biology

authors： Ahmad Y,Lamond AI

更新日期：2014-04-01 00:00:00

abstract：:Endosomal protein sorting governs the fate of many physiologically important proteins involved in a panoply of cellular functions. Recent discoveries have revealed a vital role for endosomally localised branched actin patches in facilitating protein sorting. The formation of the actin patches has been shown to require...

journal_title：Trends in cell biology

authors： Seaman MN,Gautreau A,Billadeau DD

更新日期：2013-11-01 00:00:00

abstract：:Recent work has revealed that mitochondria and chloroplasts are subject to direct control by the ubiquitin-proteasome system (UPS). Ubiquitin E3 ligases are present at the outer membrane of both organelles where they mediate ubiquitination and turnover of other organellar proteins. Both organelles exhibit remarkable s...

journal_title：Trends in cell biology

authors： Ling Q,Jarvis P

更新日期：2013-08-01 00:00:00

abstract：:In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these ...

journal_title：Trends in cell biology

authors： Andersen DS,Colombani J,Léopold P

更新日期：2013-07-01 00:00:00

abstract：:The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transact...

journal_title：Trends in cell biology

authors： Sawarkar R,Paro R

更新日期：2013-04-01 00:00:00

abstract：:The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to p...

journal_title：Trends in cell biology

authors： Wang F,Higgins JM

更新日期：2013-04-01 00:00:00

abstract：:Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates. Cyclin F uses a substrate recruitment strategy similar to that of the other cyclins, but its associated catalytic activity is substantially different. I...

journal_title：Trends in cell biology

authors： D'Angiolella V,Esencay M,Pagano M

更新日期：2013-03-01 00:00:00